Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients

Figure 3

Expression of bone markers in prostate cancer patient datasets. (a) Graphs show the mRNA levels of the genes VDR, RUNX2, vimentin, TNFSF11, BMP-2, and PTX3 in metastatic castration resistant prostate cancer (CRPC) and primary prostate tumours (primary). (b) Unsupervised hierarchical clustering of metastatic (WA) and primary (T) prostate cancers based on expression of the indicated gene set. Metastatic samples are labelled in red; primary samples are labelled in black. (c) Unsupervised hierarchical clustering of primary (prostate) and metastatic prostate cancers at the indicated distinct metastatic sites. Primary/localized samples are indicated in black; distal metastases are indicated in red.

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