Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients

Figure 5

Ultrastructural and molecular imaging analysis. (a) Electron micrograph shows prostate cancer cells of a BM− biopsy. (b) Prostate cancer cells next to calcium-phosphate calcification in a BM+ lesion. SUV max and SUV average of BM+ and BM− lesions. (c) Graph shows significant difference between the SUV max value of BM+ and BM−patients. (d) Graph shows significant difference between the SUV average value of BM+ and BM− patients. (e) Graph shows significant difference between the SUV max value of BM+ and BM− patients. (f) Dual fusion 18F-choline PET/CT image of BM+ patients. (g) Image displays numerous RUNX2-positive prostate cancer cells in BM+ patient of (e) (scale bar represents 50 µm). (h) Image displays numerous RANKL-positive prostate cancer cells in BM+ patient of (e) (scale bar represents 50 µm).

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