Accelerated ¹⁹F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement

Table 3

Biosensor relaxivity for ¹⁹F at 293 K and 9.4 Tesla obtained from Figure 3 relaxation data fitting using equations 1/T₁ = ρ₁ = ρ₁^[Rx] ∗ [Rx] +  and 1/T₂ = ρ₂ = ρ₂^[Rx] ∗ [Rx] + .

	Intact biosensor	Cleaved biosensor
ρ1	ρ1 = 92.9 ± 7.3 s^−1	ρ1^[Rx] = 2.76 ± 0.40 s^−1 mM^−1
	T1 = 10.7 ± 1.0 ms (Figure 3(a))	ρ1^0 = +0.98 ± 0.33 s^−1 (Figure 3(c))
ρ2	ρ2 = 289 ± 4 s^−1	ρ2^[Rx] = 9.85 ± 0.37 s^−1·mM^−1
	T2 = 3.46 ± 0.42 ms (Figure 3(b))	ρ2^0 = 3.90 ± 0.30 s^−1 (Figure 3(d))

Data are for biosensor with MMP-2/-9-specific sequence using MMP-2 as the cleavage enzyme.