Radiosynthesis and Preclinical Evaluation of ¹¹C-VA426, a Cyclooxygenase-2 Selective Ligand

Figure 7

Ex vivo biodistribution of ¹¹C-VA426 in the brain inflammation model; neuroinflammation was induced by intracranial LPS administration into the right nigrostriatal region (PBS on the left, as control), on two experimental groups (n = 9 per group). The first group, LPS 1d, was injected with ¹¹C-VA426 one day after LPS treatment (n = 3 per time point) and the second group, LPS 12d, twelve days after LPS treatment (n = 3 per time point). Uptake values in brain areas are expressed as percentage of injected dose per gram of tissue (%ID/g) ( vs. right cortex, for paired Student’s t-test).

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