Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes

<div>Proteolysis imaging by MRI. Proteolysis of peptide-locked nitroxide (1) into a free nitroxide (2) by neutrophil elastase creating high contrast in vivo by OMRI and EPR shift in vitro. Black arrowhead designates cleavage site in the amino acid specific sequence.</div>

Contrast Media & Molecular Imaging

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Figure 4

Figure 4: Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes 