T2 Relaxation Time Obtained from Magnetic Resonance Imaging of the Liver Is a Useful Parameter for Use in the Construction of a Murine Model of Iron Overload

Figure 2

(a) Histopathological analysis for hepatic hemosiderin deposition in iron-loaded mice on Day 3 after administration of iron-dextran or dextran (control = dextran; Iron 0.1 = 0.1 mg iron-dextran/mouse; Iron 0.5 = 0.5 mg iron-dextran/mouse; Iron 2.5 = 2.5 mg iron-dextran/mouse). (b) Liver iron content, (c) serum hepcidin levels, and (d) serum ferritin levels on Day 3 after administration of iron-dextran or dextran (control = dextran; Iron 0.1 = 0.1 mg iron-dextran/mouse; Iron 0.5 = 0.5 mg iron-dextran/mouse; Iron 2.5 = 2.5 mg iron-dextran/mouse). Results are expressed as mean + SD. Five mice from each group were used. Statistical significances were analyzed by Dunnett’s test. .

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