Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents

<div>Compartment model for targeted and control agent kinetics in a lymph node. In each case, the agents are assumed to enter and leave any lymph node region-of-interest at a rate of the lymph fluid flow (Fl), governed by the concentration input curve (Cl). The targeted agent is then able to reach an equilibrium between bound (Cb) and unbound (Cf) states with a rate constant of binding, k3, and a rate constant of dissociation, k4. The control agent is unable to bind and is only assumed to be in a freely associated space, Cf,T.</div>

Contrast Media & Molecular Imaging

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Figure 1

Figure 1: Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents 

Figure 1 | Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents 