^99mTc-Labeled LyP-1 for SPECT Imaging of Triple Negative Breast Cancer

Figure 7

SPECT imaging of ^99mTc-LyP-1 in vivo. SPECT images of nude mice bearing 4T1 xenografted tumors at different time points after intravenous injection of ^99mTc-LyP-1 (a). The tumor-to-muscle (T/M) ratios of ^99mTc-LyP-1 and ^99mTc-ARAL were compared at 0.5 min, 0.5 h, 1 h, 2 h, 4 h, and 6 h (b). The relative SPECT signal intensities of ex vivo tumors and major organs (c) at 6 h postinjection of ^99mTc-LyP-1 or ^99mTc-ARAL. The ratio of tumor/liver (T/L) and tumor/kidney (T/K) of ^99mTc-LyP-1 (d) and ^99mTc-ARAL (e) was compared at 6 h postinjection.

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