Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validation

Algorithm 1

Hybrid CA model of vascular tumor growth and treatment.

INPUT: Cell and vessel location in tissue region

while  𝑡𝑖𝑚𝑒<𝑇_max  do

 STEP 1: Numerically solve system of PDEs

 STEP 2: Determine vessel response to PDE solution

 STEP 3: Evolve each automaton cell

 STEP 4: Apply treatment (if treatment is given at this time)

end while