Research Article

Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model

Figure 2

Simulation results of membrane potential ( ) (a), cytoplasmic Ca2+ concentration (b), SR luminal Ca2+ concentration ([Ca2+]SR) (c), and (d) during a single twitch. The red curve represents the time course of those parameters in failing myocytes, while the blue curve is the time course of those parameters in control myocytes.
183978.fig.002a
(a)
183978.fig.002b
(b)
183978.fig.002c
(c)
183978.fig.002d
(d)