The HYP-RT Hypoxic Tumour Radiotherapy Algorithm and Accelerated Repopulation Dose per Fraction Study

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="363564.fig.005a" src="https://static.hindawi.com/articles/cmmm/volume-2012/363564/figures/363564.fig.005a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Oxic vs. moderately hypoxic tumour doubling time (<svg height="15.7" id="M13" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 21.625 15.7" width="21.625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.55)"><path d="M649 676l-22 -187l-33 -2q3 56 -12 94q-8 20 -31.5 26.5t-86.5 6.5h-74l-90 -491q-4 -23 -6 -36.5t1 -25t7 -16.5t18 -9t27 -5t41 -3l-6 -28h-286l4 28q68 5 84 18.5t28 76.5l94 491h-55q-74 0 -100.5 -6t-41.5 -23q-24 -29 -54 -98l-32 1q32 98 53 188h22q7 -18 15 -22
t37 -4h417q23 0 33.5 5t25.5 21h23z" id="x1D447"></path></g>
<g transform="matrix(.012,0,0,-.012,11.388,15.638)"><path d="M780 372q0 -191 -178 -297q-128 -75 -335 -75h-250l7 27q61 7 77 22t28 76l77 398q11 62 0 76.5t-77 22.5l6 28h292q164 0 258.5 -67.5t94.5 -210.5zM678 375q0 119 -73 180.5t-201 61.5q-62 0 -82 -13q-17 -7 -25 -53l-80 -427q-8 -47 -4 -62t26 -20q24 -6 80 -6
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</svg>) versus the symmetrical stem cell division probability (<i>Spercent</i>).</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="363564.fig.005b" src="https://static.hindawi.com/articles/cmmm/volume-2012/363564/figures/363564.fig.005b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Oxic vs. moderately hypoxic tumour total growth time (10<sup>8</sup> cells) versus the symmetrical stem cell division probability (<i>Spercent</i>).</td></tr></table></td></tr></table>

<table>(a) The doubling time (<i>T<sub>D</sub></i>), and (b) the total tumour growth times, versus the symmetrical stem cell division probability (<i>Spercent</i>) ranging from 2 to 30% for oxic and moderately hypoxic simulations of tumour growth up to 10<sup>8</sup> cells. In Figure (a) the size of the error bars are negligible.</table>

Computational and Mathematical Methods in Medicine

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Figure 5

Figure 5: The HYP-RT Hypoxic Tumour Radiotherapy Algorithm and Accelerated Repopulation Dose per Fraction Study 