Table 2: The results of the multiple linear regression analysis for antiretroviral drugs versus MRTD. In the training, dataset only two of the six molecular descriptors showed a statistically significant correlation with therapeutic dose, that is, P[BD] ( = 0.0349) and ASol ( = 0.0140). A multiple regression model equation coefficients are listed with there standard errors, coefficient of determination ( ), multiple correlation coefficient (MCC = 0.7727) and residual standard deviation (RSD = 33.89).

Multiple linear regression RSD = 33.89MCC = 0.7727
independent variablesCoefficientSE -value

Constant−34.3303
AlogP−12.19956.69760.0873−0.221
ASol2.12390.76970.01400.476
logBioHL15.90008.03770.0654−0.071
MW0.21590.10150.0494−0.116
OxidHL5.65892.84780.06430.448
P[BD]46.513320.17460.03490.427

ANOVAF-ratio = 3.9507