Research Article

Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain: Neurochemical State Dependence of Global and Local Topological Properties

Figure 5

Scatter plots of c versus k for all nodes, at the voxel scale. Overall, low degree (k) nodes were associated with a spread of clustering (c) behaviors, whereas the nodes of highest degree had clustering coefficients toward the middle of the range. Compared with vehicle (d), the active-drug networks (a–c) had a greater range in both k and c. Amphetamine and nicotine showed a differential shift in the k-c distributions between cortical and subcortical nodes, whereas for fluoxetine nodes in both brain subdivisions were shifted to higher values. The green lines indicate cutoff values used to identify nodes whose k and/or c characteristics were outside the range associated with the vehicle state (see text).
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