Coarse-Grained Simulation of Myosin-V Movement

Table 3

Dwell time rate constants. The mean rate constants (frames⁻¹), with standard deviations below, are tabulated from fits of the single exponential equation (1) to dwell time distribution histograms (Figure 8) for the first head (𝑘₁), the second head (𝑘₂), and both heads (𝑘₁₂) of the myosin dimer model for each leg length (IQ units) of the myoV-2IQ, myoV-4IQ, and myoV-6IQ simulations.

Rate const.	𝑘1	𝑘2	𝑘12
2-IQ leg
Mean	3.909×10^−3	4.004×10^−3	3.957×10^−3
Std.dev.	1.096×10^−4	1.089×10^−5	6.451×10^−5
4-IQ leg
Mean	1.321×10^−2	1.089×10^−2	1.204×10^−2
Std.dev.	5.476×10^−4	5.228×10^−4	3.192×10^−4
6-IQ leg
Mean	1.507×10^−2	1.450×10^−2	1.479×10^−2
Std.dev.	1.947×10^−4	3.343×10^−4	2.112×10^−4