850754.fig.003a
(a) Untreated
850754.fig.003b
(b) Act. OT1 + Anti-CD137
850754.fig.003c
(c) Untreated
850754.fig.003d
(d) Act. OT1 + Anti-CD137
Figure 3: Comparison of melanoma surface ( ) behavior over time between mean in vivo measurements (red lines) and simulations (blue lines). (a) Comparison for the untreated case (no vaccination). (b) Comparison under the administration of the combined activated OT1 CTLs + Anti-CD137 monoclonal antibodies treatment. In silico melanoma surfaces have been estimated from the total number of melanoma cells by assuming only radial growth and a disk-shaped layout for the melanoma. (c) Absolute (orange line) and relative (green line) differences between in vivo and in silico measurements for the untreated case (no vaccination). (d) Absolute (orange line) and relative (green line) differences between in vivo and in silico measurements under the administration of the combined activated OT1 CTLs + Anti-CD137 monoclonal antibodies treatment.