Discrete-State Stochastic Models of Calcium-Regulated Calcium Influx and Subspace Dynamics Are Not Well-Approximated by ODEs That Neglect Concentration Fluctuations

Figure 10

Percentage small system deviation (Δ) as a function of unitary subspace volume 𝑣₀ and influx parameter 𝑐_∗ for multiple (a) calcium-activated channels (𝜅=0.45 μM, 𝑘⁺=0.005 μM⁻² ms⁻¹) and (b) calcium-inactivated channels (𝜅=0.63 μM, 𝑘⁺=0.05 μM⁻² ms⁻¹).

(a)

(b)