Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
Figure 3
Experimentally detected normalized cell volume (cell volume after loading/cell volume before loading) in cartilage samples obtained from experimental (ACLT) and contralateral (CNTRL) joints at four weeks (Turunen et al. 2012) [22] and nine weeks (Han et al. 2010) [23] after anterior cruciate ligament transection. Results from the fibril-reinforced poroelastic models, representing contralateral (Table 2, CNTRL model) and ACLT cartilages (Table 2, ACLT model) are also shown (simulations). In all cases, a contact pressure of 2 MPa was applied, followed by a 1200 s force relaxation. Cell volume behaviour in the nonoperated normal group was similar to contralateral cartilage [23]. Experimental data is presented as mean ± standard error of mean. , between the groups.
