Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
Figure 4
Normalized cell volume (cell volume after loading/cell volume before loading) in the simulations of the experimental loading protocol (blue, 2 MPa stress followed by force relaxation [22, 23]) and for the constant strain protocol (red, ε = 16%). The cell volume was analyzed as a function of the ECM (a) collagen fibril modulus, (b) fixed charge density, and (c) fluid fraction. Other model parameters were as in the CNTRL model (see Table 2, parametric ECM model). Above the horizontal line (- -) the cell volume is increased and under the line the cell volume is decreased.
