Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
Figure 5
Normalized cell volume (cell volume after loading/cell volume before loading) in contralateral (CNTRL) and anterior cruciate ligament transected (ACLT) models as a function of the PCM (a) collagen fibril modulus, (b) fixed charge density, and (c) fluid fraction. Both CNTRL and ACLT models were compressed until a 2 MPa contact pressure was reached. This was followed by a 1200 s force relaxation. Model parameters are presented in Table 2 (CNTRL: Parametric CNTRL PCM model, ACLT: Parametric ACLT PCM model). Above the horizontal line (- -) the cell volume is increased and under the line the cell volume is decreased. Vertical line (- -) in (b) represents the fixed charge density of the cell in the superficial zone.
