Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis

Table 1

Mechanical, structural, and compositional parameters of the ECM, PCM, and cell of the reference model. Parameters were implemented into the fibril-reinforced poroelastic swelling model of articular cartilage.

	ECM	PCM	Cell
Mechanical parameters
𝐸𝑓 (MPa)	10	0.1 * 𝐸^ECM𝑓	—
𝐸𝑚 (MPa)	0.505	0.0505	0.017
𝜐𝑚	0.15	0.15	0.30
𝑘 (10^−15 m^4/Ns)	1.9	1.9	1900
Composition
𝑛𝑓	0.85−0.15𝑧	0.85	0.61
𝑐𝐹 (mEq/mL)	0.11+0.09𝑧	0.14+0.12𝑧	0.08
Zone depth
Superficial	0.07	—	—
Middle	0.18	—	—
Deep	0.75	—	—