Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis

Table 3

Local ECM and cell strains, and cell volume in contralateral (CNTRL) and anterior cruciate ligament transected (ACLT) rabbit knee joint cartilages 4 weeks (Turunen et al. [22], 𝑁 = 8 pairs of joints, 𝑛 = 77 in CNTRL group cells, 𝑛 = 79 in ACLT group cells) and 9 weeks (Han et al. [23], 𝑁 = 4 pairs of joints, 𝑛 = 48 cells in both groups) after ACL transection. Experimental data is presented as mean ± standard error of mean.

	Turunen et al. [22]		Han et al. [23]		Simulations
	CNTRL	ACLT	CNTRL	ACLT	CNTRL	ACLT
Local axial ECM strain (%)	43 ± 4	47 ± 4	27 ± 5	38 ± 4**	30	39
Local transverse ECM strain (%)	17 ± 4	20 ± 3	8 ± 3	14 ± 3*	6	11
Change in cell height (%)	24 ± 2	17 ± 2**	18 ± 2	12 ± 2	29	38
Change in cell width^† (%)	13 ± 1	22 ± 1***	7 ± 1	12 ± 1**	20	36
Change in cell volume (%)	−5 ± 1	24 ± 4***	−8 ± 2	8 ± 2**	−4	7

^†In the experiments, cell width refers to an average width and depth.
^∗𝑃<0.05, **𝑃 < 0.005, ***𝑃 < 0.001 between CNTRL and ACLT groups.