Computational and Mathematical Methods in Medicine

Research Article

The Number of Candidate Variants in Exome Sequencing for Mendelian Disease under No Genetic Heterogeneity

Table 2

The expected number of SNVs after filtering in dominant disease using unrelated individuals.



	/: 100%	/: 90%	/: 80%	/: 100% () 0% ()	/: 100% () 0% ()	/: ≥80% () 0% ()	/: ≥80% () 0% ()	/: ≥80% () ≤20% ()

1	19999.50	—	—	—	—	—	—	—
2	12221.92	—	—	7777.58	7777.58	—	—	—
3	9333.10	—	—	—	2888.82	—	—	—
4	7761.71	—	—	1317.43	1571.39	—	—	—
5	6751.15	—	11803.94	—	1010.56	—	—	—
10	4450.20	7292.89	9899.74	12.68	284.27	—	—	487.69
11	4209.42	—	—	—	240.77	1325.27	—	—
13	3821.65	—	—	—	180.60	—	111.07	—
20	2992.04	6220.39	8915.41	0.01	87.51	—	—	28.51
21	2911.32	—	—	—	80.72	944.79	—	—
23	2767.09	—	—	—	69.48	—	45.77	—
50	1808.56	5540.39	8311.92	—	19.82	—	—	0.02
51	1789.36	—	—	—	—	736.85	—	—
53	1752.68	—	—	—	—	—	21.74	—
100	1249.75	5306.36	8108.38	—	—	—	—	—