A Review of the Combination of Experimental Measurements and Fibril-Reinforced Modeling for Investigation of Articular Cartilage and Chondrocyte Response to Loading
Figure 7
(a) The measurement setup of osmotic loading experiment of cells within intact cartilage tissue, a representative confocal microscopic image and a 3D presentation of a cell used for cell volume and morphology analysis. (b) Chondrocyte volume change in osmotically or mechanically loaded intact cartilage, cartilage explant, collagenase-degraded cartilage, and osteoarthritic cartilage (as a result of anterior cruciate transection). Experimentally determined cell volume change in osmotically challenged intact cartilage tissue is compared with a computational, microscale, fibril reinforced model (<1 ~ volume decrease, >1 ~ volume increase).
