- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents

Computational and Mathematical Methods in Medicine

Volume 2013 (2013), Article ID 425184, 8 pages

http://dx.doi.org/10.1155/2013/425184

## Recent Progress on the Factorization Method for Electrical Impedance Tomography

Department of Mathematics, University of Würzburg, 97074 Würzburg, Germany

Received 12 November 2012; Accepted 15 March 2013

Academic Editor: Bill Lionheart

Copyright © 2013 Bastian Harrach. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

#### Abstract

The Factorization Method is a noniterative method to detect the shape and position of conductivity anomalies inside an object. The method was introduced by Kirsch for inverse scattering problems and extended to electrical impedance tomography (EIT) by Brühl and Hanke. Since these pioneering works, substantial progress has been made on the theoretical foundations of the method. The necessary assumptions have been weakened, and the proofs have been considerably simplified. In this work, we aim to summarize this progress and present a state-of-the-art formulation of the Factorization Method for EIT with continuous data. In particular, we formulate the method for general piecewise analytic conductivities and give short and self-contained proofs.

#### 1. Introduction

Electrical impedance tomography (EIT) aims to reconstruct the spatial conductivity distribution inside an imaging subject from current-voltage measurements on a part of its surface . Mathematically, this leads to the problem of recovering the coefficient in the elliptic partial differential equation from knowledge of the corresponding Neumann-to-Dirichlet operator (NtD) where is the solution of (1). We describe the precise mathematical setting in Section 2.1.

In several applications, EIT is used to determine the position of conductivity changes. This includes anomaly detection problems, where is compared to a reference NtD in order to determine, if and where differs from a known background conductivity . This problem also appears in time-difference EIT, where measurements at different times are compared to monitor temporal conductivity changes. These applications lead to the *shape reconstruction* problem of determining the support of from and .

A prominent noniterative shape reconstruction method is the Factorization Method. It was introduced by Kirsch [1] for inverse scattering problems and extended to EIT by Brühl and Hanke [2–4]. In its original form (cf. [4]), the method assumes that
where is a union of separated, smoothly bounded, and simply connected domains, on which there is a conductivity jump of at least ; that is,
The method then characterizes the unknown shape by a *range criterion*. For all unit vectors , ,
where is the so-called *dipole function*, that is, the solution of
The range criterion (5) can be implemented numerically, so that each point can be tested whether it belongs to the unknown inclusion or not.

Substantial progress has been made on the Factorization Method since the original works of Kirsch, Brühl, and Hanke. In the following, we restrict ourselves to progress in the context of EIT. Overviews on the FM for EIT have been given by Hanke and Brühl [5], in the book of Kirsch and Grinberg [6], and in a recent chapter of Hanke and Kirsch in Scherzer's Handbook of Mathematical Methods in Imaging [7]. The FM for EIT has been treated as a special case of more general elliptic problems by Kirsch [8], the author [9], and by Nachman, Päivärinta and Teirilä [10]. A half-space setting has been considered by Hanke and Schappel [11]. Electrode models have been covered in the works of Brühl, Lechleiter, Hakula, Hanke, Hyvönen and Pursiainen [5, 12–15]. The FM has been extended to the complex conductivity case arising in frequency-difference EIT by Seo, Woo and the author [16, 17]. A priori separated indefinite inclusions have been treated by Schmitt [18], and Schmitt and Kirsch discussed the determination of the contrast level in the context of the FM for EIT in [19]. Hyvönen and the author have removed the assumptions on the inclusion contrast and boundary regularity in [20], and [21] discusses the relation of the FM to localized potentials.

In this work, we aim to summarize the theoretical progress and present a state-of-the-art formulation of the Factorization Method for EIT with continuous data. In particular, we will formulate the method for general piecewise analytic conductivities and give short and self-contained proofs.

#### 2. Setting and Auxiliary Results

##### 2.1. The Setting

We start by making the mathematical setting precise. Let , , denote a bounded domain with smooth boundary and outer normal vector . Let be an open part of the boundary. denotes the subspace of -functions with positive essential infima. and denote the spaces of - and -functions with vanishing integral mean on (resp., ).

For and , there exists a unique solution of the elliptic partial differential equation so that we can define the Neumann-to-Dirichlet operator (NtD) where solves (7). is a self-adjoint, compact linear operator.

Let be piecewise analytic. For each point that has a neighborhood in which is analytic, and each unit vector , , let be the solution of
is called a *dipole function*.

##### 2.2. Auxiliary Results

Our presentation of the Factorization Method in the next section relies on the following four lemmas. The first lemma is frequently called a *monotony lemma* since it shows that a larger conductivity leads to a smaller NtD. More precisely, it shows a relation between the difference of two NtDs and the difference of the corresponding conductivities and the interior energy of an electric potential. The second lemma shows that this energy term is the image of the adjoint of an auxiliary virtual measurement operator that is defined on a subregion of . The third lemma is a functional analytic relation between the norm of an image of an operator and the range of its adjoint. Together with the first two lemmas, it implies that the range of the auxiliary virtual measurement operator can be calculated from the NtDs. Finally, using the previous dipole functions, the last lemma shows that the range of the auxiliary virtual measurement operator determines the region on which they are defined.

We start with the monotony lemma.

Lemma 1. *Let . Then, for all , **where we abbreviated , , and . *

*Proof. *The lemma seems to go back to Ikehata, Kang, Seo, and Sheen [22, 23], cf. also the similar arguments in Kirsch [8], Ide et al. [24], and in the works of Seo and the author [16, 25]. For the sake of completeness, we copy the short proof from [25]. For all , we have that
Hence, from
we obtain that
which already yields the first asserted inequality.

By interchanging and , we conclude that
and, hence, obtain the second inequality.

Given a reference conductivity and a measurable subset , we define the *virtual measurement operator * by
where solves
The energy term in Lemma 1 can be identified with the norm of the adjoint of this virtual measurement operator.

Lemma 2. *The adjoint operator of is given by
**
where solves
*

*Proof. *For all and , we have that
which shows the assertion.

The following functional analytic lemma uses bounds on the image of an operator to characterize the range of its dual operator.

Lemma 3. * Let and be real Hilbert spaces with inner products and , respectively. Let and . Then,**In particular, if , , and are three real Hilbert spaces, , , and if there exists with
**
then .*

*Proof. *The assertion can be generalized to Banach spaces, and, in that context, it is called the “14th important property of Banach spaces” in Bourbaki [26]. For the sake of completeness, we rewrite the proof from [27] to Hilbert spaces.

If , then there exists such that . Hence,
so that the assertion holds with .

Now let be such that there exists with for all . We define
Then, is a well-defined, continuous linear functional on . By setting it to zero on , we can extend to a continuous linear functional on . Using the Riesz theorem, it follows that there exists with
Hence, for all , we have
so that .

The last lemma shows that the range of the virtual measurement operator determines the region on which it is defined. We state the lemma for a simple special case, a generalized version of the lemma will be formulated in Section 3.2.

Lemma 4. *Let , be open, and have a connected complement .**Then, for all unit vectors , , and every point , it holds that
*

*Proof. *The proof is similar to the one of [21, Lemma 2.9].

First, let and be such that . We choose
and let be the zero continuation of to .

Then, the function
fulfills , and, for all ,
This shows that .

Now let . Let be the function from the definition of . Then,
so that it follows by unique continuation that in the connected set .

If , then , and thus , which contradicts that in . Hence, .

#### 3. The Factorization Method

Now we will formulate the Factorization Method and characterize a region where a conductivity differs from a reference conductivity by a range criterion. Before we turn to a new general formulation of the method, we first state it for a special case that is similar to the one that was treated in the original works of Brühl and Hanke [3, 4].

##### 3.1. The Factorization Method for a Simple Special Case

Theorem 5. *Let and , where is an open set so that has a connected complement . Then, for all , , and all dipole directions , ,
*

*Proof. *The monotony Lemma 1 yields that for all ,
Hence, , and, using Lemma 2, we can restate this in the form
Using the functional analytic Lemma 3, this implies that
and thus the assertion follows from the relation between and in Lemma 4.

Obviously, the same arguments can be used to treat the case , when there exists a conductivity jump so that either

##### 3.2. The Factorization Method for the General Piecewise Analytic Case

Now we drop the assumptions that the background is constant, that there is a clear conductivity jump, and that the complement of the inclusions is connected. We will merely assume that the reference conductivity is a piecewise analytic function and that either or . Roughly speaking, under this general assumption, the Factorization Method then characterizes the support of up to holes in the support that have no connections to . For a precise formulation, we use the concept of the inner and outer support from [28] that has been inspired by the use of the infinity support of Kusiak and Sylvester [29]; see also [25, 30].

*Definition 6. *A relatively open set is called *connected* to if is connected and .

For a measurable function , we define (a) the *support * as the complement (in ) of the union of those relatively open , for which , (b) the *inner support * as the union of those open sets , for which , (c) the *outer support * as the complement (in ) of the union of those relatively open that are connected to and for which . The interior of a set is denoted by and its closure (with respect to ) by . If is measurable, we also define(d). It is easily checked that .

With this concept, we can extend the range characterization in Lemma 4 to a general setting (see also Remark 9 later).

Lemma 7. * Let be piecewise analytic. Let be measurable.**Then, for all unit vectors , , and every point that has a neighborhood in which is analytic,
**
and
*

*Proof. *If , then there exists a small ball , and the first assertion follows as in the proof of Lemma 4.

To show the second assertion, let , and let be the function from the definition of , so that (as in the proof of Lemma 4)
Assume that . Then, there exists a relatively open that is connected to and contains . Hence, by unique continuation, it follows that , and we obtain the same contradiction as in the proof of Lemma 4.

Now, we can formulate and prove the Factorization Method for general piecewise analytic conductivities.

Theorem 8. * Let , and let be a piecewise analytic function. Let either
**
Then, for all that have a neighborhood in which is analytic, as well as all unit vectors , ,
**
and
*

*Proof. *Let have a neighborhood in which is analytic, and let be a unit vector with . We only prove the assertions for . The other case is completely analogous.

First, let . Then there exists a small ball and so that on . Using the monotony Lemma 1, it follows that, for all ,
Using the functional analytic Lemma 3, we obtain that
and Lemma 7 yields that
On the other hand, with , the monotony Lemma 1 shows that for all ,
so that we obtain from the functional analytic Lemma 3
Hence, Lemma 7 yields that

*Remark 9. * Theorem 8 shows that the Factorization Method is able to detect the support of a conductivity difference up to the difference between the outer and the inner support, that is, roughly speaking, up to holes in the support that have no connections to the boundary. It leaves open whether points in such holes will fulfill the range criterion of the Factorization Method or not.

A result of Hyvönen and the author [30, Lemma 2.5] shows that for every smooth domain with and every unit vector , ,
implies
In that sense, we can expect that holes in the support will be filled up and that the set detected by the Factorization Method is essentially the outer support of the conductivity difference.

##### 3.3. The Factorization Method for the Indefinite Case

It is a long standing open theoretical problem whether the range criterion of the Factorization Method holds true without the *definiteness assumption* that on or on . However, Grinberg, Kirsch, and Schmitt [18, 31] showed how to *exclude* a region from , in such a way that the Factorization Method only requires the definiteness assumption on . In this subsection, we show how their idea can be incorporated into our formulation of the method.

To point out the main idea, we first formulate the result for a simple special case. Let us stress that, for , it is not known whether However, we can still use the Factorization Method if we have some a priori knowledge that separates and . More precisely, if we know a subset that contains without intersecting , then we can use the Factorization Method to find (and thus ).

Theorem 10. *Let and , where are open. Let be an open set.*(a)* If and has a connected complement, then for all , , and all dipole directions , ,
*(b)* If and has a connected complement, then for all , , and all dipole directions , ,
*

*Proof. *The monotony Lemma 1 yields that for all ,
Since (cf. Lemma 2)
it follows for case (a) that
Using the functional analytic Lemma 3, this implies that
so that the assertion (a) follows from Lemma 4.

In case (b), we obtain that
and the same arguments as above yield the assertion.

We can also extend these ideas to the general setting of Section 3.2.

Theorem 11. *Let and let be a piecewise analytic function. Let be a measurable set.**Choose such that
*(a)* If on , then for all that have a neighborhood in which is analytic, as well as all unit vectors , ,
* *and
*(b)* If on , then for all that have a neighborhood in which is analytic, as well as all unit vectors , ,
* *and
*

*Proof. *For every with , there exists a small ball and so that on . Using the monotony Lemma 1, it follows that, for all ,
As in the previous proofs, we obtain from Lemmas 2 and 3 that
so that the first implication of (a) follows from Lemma 7.

The monotony Lemma 1 also implies that
so that the second implication of (a) follows from Lemmas 2, 3, and 7. Assertion (b) can be proven analogously.

Remark 9 also applies to this case.

#### 4. Conclusions and Remarks

The Factorization Method can be used to detect regions in which a conductivity differs from a known reference conductivity. In this work, we summarized the progress on the method's theoretical foundation. We formulated the method for general piecewise analytic conductivities and gave comparatively simple and self-contained proofs. We also showed how the idea of excluding a part of the imaging region can be incorporated into this formulation.

The regularity assumptions can be weakened even further. Our proofs only require unique continuation arguments for the reference conductivity and the existence of the dipole functions.

Two major open theoretical questions still exist in the context of the Factorization Method. The theoretical justification of the method requires a definiteness condition (on the whole domain or after excluding an a priori known part of the domain). It is unknown whether the method's range criterion holds without such a definiteness condition. The second open question concerns the numerical stability of the method's range criterion. So far, there are no rigorous convergence results for numerical implementations of this range criterion (see, however, Lechleiter [32] for a first step in this direction). As a promising approach to overcome both problems, we would like to point out the recent work on monotony-based methods [28].

#### Acknowledgments

This paper was funded by the German Research Foundation (DFG) and the University of Würzburg in the funding programme Open Access Publishing.

#### References

- A. Kirsch, “Characterization of the shape of a scattering obstacle using the spectral data of the far field operator,”
*Inverse Problems*, vol. 14, no. 6, pp. 1489–1512, 1998. View at Publisher · View at Google Scholar · View at Scopus - M. Brühl,
*Gebietserkennung in der elektrischen Impedanztomographie [Ph.D. thesis]*, Universitat Karlsruhe, 1999. - M. Brühl and M. Hanke, “Numerical implementation of two noniterative methods for locating inclusions by impedance tomography,”
*Inverse Problems*, vol. 16, no. 4, pp. 1029–1042, 2000. View at Publisher · View at Google Scholar · View at Scopus - M. Brühl, “Explicit characterization of inclusions in electrical impedance tomography,”
*SIAM Journal on Mathematical Analysis*, vol. 32, no. 6, pp. 1327–1341, 2001. View at Publisher · View at Google Scholar · View at Scopus - M. Hanke and M. Brühl, “Recent progress in electrical impedance tomography,”
*Inverse Problems*, vol. 19, no. 6, pp. S65–S90, 2003. View at Publisher · View at Google Scholar · View at Scopus - A. Kirsch and N. Grinberg,
*The Factorization Method for Inverse Problems*, vol. 36 of*Oxford Lecture Series in Mathematics and Its Applications*, Oxford University Press, Oxford, UK, 2007. - M. Hanke and A. Kirsch, “Sampling methods,” in
*Handbook of Mathematical Models in Imaging*, O. Scherzer, Ed., pp. 501–550, Springer, 2011. - A. Kirsch, “The factorization method for a class of inverse elliptic problems,”
*Mathematische Nachrichten*, vol. 278, pp. 258–277, 2005. - B. Gebauer, “The Factorization Method for real elliptic problems,”
*Zeitschrift für Analysis und ihre Anwendung*, vol. 25, no. 1, pp. 81–102, 2006. View at Scopus - A. I. Nachman, L. Päivärinta, and A. Teirilä, “On imaging obstacles inside inhomogeneous media,”
*Journal of Functional Analysis*, vol. 252, no. 2, pp. 490–516, 2007. View at Publisher · View at Google Scholar · View at Scopus - M. Hanke and B. Schappel, “The factorization method for electrical impedance tomography in the half-space,”
*SIAM Journal on Applied Mathematics*, vol. 68, no. 4, pp. 907–924, 2008. View at Publisher · View at Google Scholar · View at Scopus - N. Hyvönen, “Complete electrode model of electrical impedance tomography: approximation properties and characterization of inclusions,”
*SIAM Journal on Applied Mathematics*, vol. 64, pp. 902–931, 2004. - A. Lechleiter, N. Hyvönen, and H. Hakula, “The factorization method applied to the complete electrode model of impedance tomography,”
*SIAM Journal on Applied Mathematics*, vol. 68, no. 4, pp. 1097–1121, 2008. View at Publisher · View at Google Scholar · View at Scopus - N. Hyvönen, H. Hakula, and S. Pursiainen, “Numerical implementation of the factorization method within the complete electrode model of electrical impedance tomography,”
*Inverse Problems and Imaging*, vol. 1, pp. 299–317, 2007. - H. Hakula and N. Hyvönen, “On computation of test dipoles for factorization method,”
*BIT Numerical Mathematics*, vol. 49, no. 1, pp. 75–91, 2009. View at Publisher · View at Google Scholar · View at Scopus - B. Harrach and J. K. Seo, “Detecting inclusions in electrical impedance tomography without reference measurements,”
*SIAM Journal on Applied Mathematics*, vol. 69, no. 6, pp. 1662–1681, 2009. View at Publisher · View at Google Scholar · View at Scopus - B. Harrach, J. K. Seo, and E. J. Woo, “Factorization method and its physical justification in frequency-difference electrical impedance tomography,”
*IEEE Transactions on Medical Imaging*, vol. 29, no. 11, pp. 1918–1926, 2010. - S. Schmitt, “The factorization method for EIT in the case of mixed inclusions,”
*Inverse Problems*, vol. 25, no. 6, Article ID 065012, 2009. View at Publisher · View at Google Scholar · View at Scopus - S. Schmitt and A. Kirsch, “A factorization scheme for determining conductivity contrasts in impedance tomography,”
*Inverse Problems*, vol. 27, Article ID 095005, 2011. - B. Gebauer and N. Hyvönen, “Factorization method and irregular inclusions in electrical impedance tomography,”
*Inverse Problems*, vol. 23, no. 5, pp. 2159–2170, 2007. View at Publisher · View at Google Scholar · View at Scopus - B. Gebauer, “Localized potentials in electrical impedance tomography,”
*Inverse Problems and Imaging*, vol. 2, pp. 251–269, 2008. - H. Kang, J. K. Seo, and D. Sheen, “The inverse conductivity problem with one measurement: Stability and estimation of size,”
*SIAM Journal on Mathematical Analysis*, vol. 28, no. 6, pp. 1389–1405, 1997. View at Scopus - M. Ikehata, “Size estimation of inclusion,”
*Journal of Inverse and Ill-Posed Problems*, vol. 6, no. 2, pp. 127–140, 1998. - T. Ide, H. Isozaki, S. Nakata, S. Siltanen, and G. Uhlmann, “Probing for electrical inclusions with complex spherical waves,”
*Communications on Pure and Applied Mathematics*, vol. 60, no. 10, pp. 1415–1442, 2007. View at Publisher · View at Google Scholar · View at Scopus - B. Harrach and J. K. Seo, “Exact shape-reconstruction by one-step linearization in electrical impedance tomography,”
*The SIAM Journal on Mathematical Analysis*, vol. 42, no. 4, pp. 1505–1518, 2010. - N. Bourbaki,
*Elements of Mathematics, Topological Vector Spaces*, chapters 1–5, Springer, Berlin, Germany, 2003. - F. Frühauf, B. Gebauer, and O. Scherzer, “Detecting interfaces in a parabolic-elliptic problem from surface measurements,”
*SIAM Journal on Numerical Analysis*, vol. 45, no. 2, pp. 810–836, 2007. View at Publisher · View at Google Scholar · View at Scopus - B. Harrach and M. Ullrich, “Monotony based shape reconstruction in electrical impedance tomography,” submitted for publication.
- S. Kusiak and J. Sylvester, “The scattering support,”
*Communications on Pure and Applied Mathematics*, vol. 56, no. 11, pp. 1525–1548, 2003. View at Publisher · View at Google Scholar · View at Scopus - B. Gebauer and N. Hyvönen, “Factorization method and inclusions of mixed type in an inverse elliptic boundary value problem,”
*Inverse Problems and Imaging*, vol. 2, pp. 355–372, 2008. - N. I. Grinberg and A. Kirsch, “The factorization method for obstacles with a-priori separated sound-soft and sound-hard parts,”
*Mathematics and Computers in Simulation*, vol. 66, no. 4-5, pp. 267–279, 2004. View at Publisher · View at Google Scholar · View at Scopus - A. Lechleiter, “A regularization technique for the factorization method,”
*Inverse Problems*, vol. 22, no. 5, pp. 1605–1625, 2006. View at Publisher · View at Google Scholar · View at Scopus