|
| Model | Parameter | Description | Value and unit |
|
| | | Tumor growth parameter | 0.192 day−1 |
| | | Endothelial stimulation parameter | 5.85 day−1 |
| | | Endothelial inhibition parameter | 0.00873 day−1 mm−2/3 |
| | | Natural mortality of endothelial cells | 0 day−1 |
| Hahnfeldt et al. [12] | | Antiangiogenic killing parameter | 0.15 kg mg−1 |
| | | Cytostatic killing parameter for endothelial cells | 0.26 kg mg−1 |
| | | Cytostatic killing parameter for cancer cells | 0.34 kg mg−1 |
| | | Dose of angiogenic inhibitor | 2 mg kg−1 day−1 |
| | | Dose of cytotoxic drugs | 2 mg kg−1 day−1 |
|
| Hahnfeldt et al. with “pruning” effect [25] | Same as in the previous model, is different. |
| Cytostatic killing parameter for cancer cells | Depends on vessel density, calculated by equation:
where, , , |
|
| | | Tumor growth parameter | 0.192 day−1 |
| | | Immature endothelial stimulation parameter | 5.85 day−1 |
| | | Immature endothelial inhibition parameter | 0.00873 day−1 mm−2/3 |
| | | Unstable vessels maturation parameter | 0.0756 day−1 |
| Benzekry et al. [13] | | Natural mortality of mature endothelial cells | 0.075 day−1 |
| | | Antiangiogenic killing parameter | 6.85 × 10−7 mg−1 mm−1 |
| | | Cytostatic killing parameter for cancer cells | 1.37 × 10−5 mg−1 mm−1 |
| | | Dose of angiogenic inhibitor | 525 mg day−1 (half dose during continuous treatment) |
| | | Dose of cytotoxic drugs | 212 mg week−1 (half dose during continuous treatment) |
|
| Three-compartment [28] | | Average transit times through compartments | 0.02 day |
| Average transit times through compartments | 0.2 day |
| Probability of mutation to resistant cell | 0.9 |
| Probability of mutation to sensitive cell | 0 |
| Endothelial stimulation parameter | 5.85 day−1 |
| Endothelial inhibition parameter | 0.00873 day−1 mm−2/3 |
| Antiangiogenic killing parameter | 9.1 kg mg−1 |
| Cytostatic killing parameter for endothelial cells | 4.7 kg mg−1 |
| Dose of angiogenic inhibitor | 1 mg kg−1 day−1 |
| Dose of cytotoxic drug | 1 mg kg−1 day−1 |
|
