Research Article
Comparison of Simple Models of Periodic Protocols for Combined Anticancer Therapy
Table 4
Proposed parameters.
| Model | Parameter | Description | Value and unit |
| | | Tumor growth parameter | 0.192 day−1 | | | Endothelial stimulation parameter | 5.85 day−1 | | | Endothelial inhibition parameter | 0.00873 day−1 mm−2/3 | | | Natural mortality of endothelial cells | 0 day−1 | | | Anti-angiogenic killing parameter | 0.01 mg−1 | | | Cytostatic killing parameter Cisplatin (for endothelial cells) | 0.0013 m2 mg−1 | Hahnfeldt et al. [12] | | Cytostatic killing parameter Cisplatin (for cancer cells) | 0.004 m2 mg−1 | | Cytostatic killing parameter Oxaliplatin (for endothelial cells) | 0.005 m2 mg−1 | | | Cytostatic killing parameter Oxaliplatin (for cancer cells) | 0.01 m2 mg−1 | | | Cytostatic killing parameter Capecitabine (for cancer cells) | 0.00008 m2 mg−1 | | | Cytostatic killing parameter Capecitabine (for endothelial cells) | 0.00002 m2 mg−1 | | | Dose of angiogenic inhibitor | Depends on protocol | | | Dose of cytotoxic drug Cisplatin | | | Dose of cytotoxic drug Capecitabine |
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