Table 4: Proposed parameters.

ModelParameterDescriptionValue and unit

Tumor growth parameter0.192 day−1
Endothelial stimulation parameter5.85 day−1
Endothelial inhibition parameter0.00873 day−1 mm−2/3
Natural mortality of endothelial cells0 day−1
Anti-angiogenic killing parameter0.01 mg−1
Cytostatic killing parameter Cisplatin (for endothelial cells)0.0013 m2 mg−1
Hahnfeldt et al. [12] Cytostatic killing parameter Cisplatin (for cancer cells)0.004 m2 mg−1
Cytostatic killing parameter Oxaliplatin (for endothelial cells)0.005 m2 mg−1
Cytostatic killing parameter Oxaliplatin (for cancer cells)0.01 m2 mg−1
Cytostatic killing parameter Capecitabine (for cancer cells)0.00008 m2 mg−1
Cytostatic killing parameter Capecitabine (for endothelial cells)0.00002 m2 mg−1
Dose of angiogenic inhibitorDepends on protocol
Dose of cytotoxic drug Cisplatin
Dose of cytotoxic drug Capecitabine