Research Article
An Entropy-Based Automated Cell Nuclei Segmentation and Quantification: Application in Analysis of Wound Healing Process
Table 1
Results of automated segmentation performance on 21 test images.
| Stain | ID/magnification | Manual quantification (cells) | Automated quantification (cells) | Accuracy (%) | Precision (%) | Sensitivity (%) | Specificity (%) |
| SMActin | Day 5–40x | 101 | 100 | 92.96 | 91 | 90.01 | 94.67 | Day 5–60x | 59 | 60 | 91.82 | 88.33 | 89.83 | 93 | Day 7–40x | 166 | 187 | 93.55 | 85.56 | 96.38 | 92.19 | Day 7–60x | 87 | 94 | 93.96 | 89.24 | 95.40 | 93.10 | Day 14–40x | 85 | 88 | 92.75 | 89.77 | 92.94 | 92.62 |
| H&E | Day 5–40x | 86 | 86 | 100 | 100 | 100 | 100 | Day 7–40x | 141 | 138 | 99.05 | 100 | 97.87 | 100 | Day 7–60x | 66 | 71 | 95.10 | 90.14 | 96.96 | 94.06 | Day 14–40x | 105 | 108 | 98.69 | 97.22 | 100 | 97.6 | Day 14–60x | 42 | 38 | 95.28 | 100 | 88.095 | 100 |
| CD-31 | Day 5–40x | 76 | 77 | 99.38 | 98.70 | 100 | 98.85 | Day 5–60x | 52 | 49 | 97.43 | 100 | 94.23 | 100 | Day 7–40x | 140 | 188 | 94.32 | 77.77 | 97.22 | 93.66 | Day 7–60x | 61 | 59 | 97.61 | 100 | 95.08 | 100 | Day 14–40x | 98 | 104 | 97.97 | 94.23 | 100 | 97.97 | Day 14–60x | 67 | 67 | 100 | 100 | 100 | 100 |
| CD-68 | Day 5–40x | 99 | 96 | 91.36 | 76.19 | 96.96 | 89.39 | Day 5–60x | 68 | 66 | 95.13 | 84.61 | 97.05 | 94.54 | Day 14–40x | 143 | 138 | 98.55 | 100 | 96.50 | 100 | Day 14–60x | 69 | 70 | 99.49 | 98.57 | 100 | 99.23 |
| Total | | 1811 | 1884 | Average | | | | 95.55 | 91.27 | 96.45 | 95.07 |
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