Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride

Table 1

Tablet formulations for preliminary trials.

Sr. No.	Ingredients	D1	D2	D3	D4	D5	D6	D7	D8	D9	D10	D11	D12
1	Drug	50	50	50	50	50	50	50	50	50	50	50	50
2	Sod. bicarbonate	60	60	60	70	60	40	50	50	50	50	50	50
3	Citric acid	30	30	30	40	30	20	25	25	25	25	25	25
4	Xanthan gum	—	40	40	40	70	—	—	—	30	40	50	50
5	Locust bean gum	150	110	100	90	80	180	180	100	70	60	50	70
6	Mannitol	5	5	15	5	5	5	—	20	20	20	20	—
7	Mg. stearate	5	5	5	5	5	5	5	5	5	5	5	5
	Total wt. (mg)	300	300	300	300	300	300	310	250	250	250	250	250

All the weights are in mg.