Age-Dependent Estimates of the Epidemiological Impact of Pandemic Influenza (H1N1-2009) in Japan
Figure 4
Comparison of the estimated proportions of infection with pandemic influenza H1N1-2009 in Japan using different methods. (a) Comparison of four different datasets. Dashed line represents the estimated influenza-like illness (ILI) cases with medical attendance based on notified number of ILI cases from sentinel medical institutions. Bold continuous line is the baseline proportion of infections based on hemagglutination inhibition assay adopting a cut-off value of 1 : 40. Thin continuous line represents the alternative serological measure of the proportion infected using a cut-off value of 1 : 20. Grey bold line shows the predicted cumulative incidence derived from the final size equation of an age-structured mathematical model based on the datasets by the end of July 2009. (b) The ratio of estimated cases with medical attendance based on notification data to the estimated proportion infected individuals based on serological data as a function of age group.
