Modeling of Non-Small Cell Lung Cancer Volume Changes during CT-Based Image Guided Radiotherapy: Patterns Observed and Clinical Implications

Table 2

Parameter comparison for the four tumor growth and therapy efficacy models.

Model	Parameter
	Td	GF	𝑇pot	γ	𝛾rec	𝐾	𝐾𝑞	𝐾𝑝	𝐷	Rini	Rind
M: minimal	●		●			●			●
St: standard	●	●	●	●			●	●	●
REC: recruitment	●	●	●	●	●		●	●	●
RES: resistant	●	●	●	●		○	○	○	●	○	○

●: Essential model parameter.
○: Model parameter options to be selected. RES model uses either parameter 𝐾 or 𝐾𝑝 and 𝐾𝑞 and either Rini or Rind.
Abbreviations:
Td: doubling time; GF: growth fraction; 𝑇_pot: tumor potential doubling time; 𝛾: rate at which quiescent cells reenter the cycle (if 𝛾rec is used, this will be the pretreatment rate); 𝛾_rec: recruitment rate 𝛾; 𝐾: fraction of cells killed by a single fraction of RT; 𝐾𝑞: fraction of quiescent cells killed by a single fraction; 𝐾𝑝: fraction of proliferating cells killed by a single fraction; 𝐷: dying rate; Rini: subpopulation of resistant cells; Rind: fraction of cells that becomes resistant after each RT exposure.