MRI-Based Multiscale Model for Electromagnetic Analysis in the Human Head with Implanted DBS

Figure 1

Workflow of the procedure for multi-scale (MS) model generation (e). Step 1: the original MRI datasets (a) μRes and (b) mRes were first rigidly registered. Step 2: the contours of the target nucleus (i.e., GPi) and the surrounding major basal ganglia nuclei were segmented on the registered μRes dataset to generate the μRes model (c). Segmentation and generation of the mRes head model (d) were described in [21]. Step 3: each segmented structure in the μRes model—that is, the caudate (μC), the putamen (μP), and the globus pallidus (μGP, i.e., combined μGPe and μGPi)—was registered with its corresponding structure in the mRes head model (mC, mP, and mGP, resp.) using a non-rigid version of the iterative closest point (ICP). The μRes model structures were propagated on the mRes model (label propagation) and the resulting dataset was a multi-scale (MS) model (e) enhanced in the basal ganglia (yellow square).