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Computational and Mathematical Methods in Medicine
Volume 2013 (2013), Article ID 706195, 20 pages
http://dx.doi.org/10.1155/2013/706195
Research Article

Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia

Received 19 November 2012; Revised 11 February 2013; Accepted 18 February 2013

Academic Editor: Henggui Zhang

Copyright © 2013 Tianruo Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A generic cardiomyocyte ionic model, whose complexity lies between a simple phenomenological formulation and a biophysically detailed ionic membrane current description, is presented. The model provides a user-defined number of ionic currents, employing two-gate Hodgkin-Huxley type kinetics. Its generic nature allows accurate reconstruction of action potential waveforms recorded experimentally from a range of cardiac myocytes. Using a multiobjective optimisation approach, the generic ionic model was optimised to accurately reproduce multiple action potential waveforms recorded from central and peripheral sinoatrial nodes and right atrial and left atrial myocytes from rabbit cardiac tissue preparations, under different electrical stimulus protocols and pharmacological conditions. When fitted simultaneously to multiple datasets, the time course of several physiologically realistic ionic currents could be reconstructed. Model behaviours tend to be well identified when extra experimental information is incorporated into the optimisation.