706195.fig.004a
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706195.fig.004b
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706195.fig.004c
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Figure 4: Multiple-dataset generic model fits to APs recorded in response to uniform and random pacing protocols. From top to bottom: AP fits in response to uniform pacing at intervals of 400 and 200 ms and a sequence of random pacing intervals (PIs). The random sequence was generated from a normal distribution of mean 275 ms and standard deviation 69 ms. The generic model with seven time-dependent currents and one leakage current was simultaneously fitted to all three experimental datasets using a single set of model parameters.