706195.fig.006a
(a)
706195.fig.006b
(b)
Figure 6: Drug-specific multiobjective optimisation. Top and bottom panels illustrate the optimised model (solid traces) overlaid with experimental AP data (dashed traces) of peripheral sinoatrial node (pSAN) APs under control conditions (a) and in the presence of 0.1 μM E-4031, a selective blocker of channels (b).