Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Table 1

Parameter values for single AP dataset-based optimisation.

Parameter	Description	cSAN	pSAN	RA
𝑔1	Maximum 𝐼1 conductance (𝜇S/cm^2)	95.71	60.29	33.55
𝐸rev,1	Reversal potential of 𝐼1 (mV)	−91.74	−92.80	−97.71
𝑘𝛼𝑝1	Maximum value of 𝛼𝑝1(s^−1)	4932.74	4990.73	3099.16
𝑠𝛼𝑝1	Slope value for 𝛼𝑝1(mV^−1)	−1.84	−2.92	−0.10
𝑘𝛽𝑝1	Maximum value of 𝛽𝑝1(s^−1)	15.26	41.15	4477.72
𝑠𝛽𝑝1	Slope value for 𝛽𝑝1(mV^−1)	2.48	5.00	0.15
𝐸𝛼𝛽𝑝1	𝐸50 value for 𝛼𝑝1 and 𝛽𝑝1(mV)	−30.44	−62.41	−77.65
𝑘𝛼𝑞1	Maximum value of 𝛼𝑞1(s^−1)	1.40	6.61	170.9
𝑠𝛼𝑞1	Slope value for 𝛼𝑞1(mV^−1)	−3.86	−2.09	−0.01
𝑘𝛽𝑞1	Maximum value of 𝛽𝑞1(s^−1)	7.92	7.81	0.01
𝑠𝛽𝑞1	Slope value for 𝛽𝑞1 (mV^−1)	0.10	0.92	0.19
𝐸𝛼𝛽𝑞1	𝐸50 value for 𝛼𝑞1 and 𝛽𝑞1(mV)	−36.17	−53.46	−80.46
𝑔2	Maximum 𝐼2 conductance (µS/cm^2)	17722.1	17966.7	9962.91
𝐸rev,2	Reversal potential of 𝐼2 (mV)	11.38	6.98	14.54
𝑘𝛼𝑝2	Maximum value of 𝛼𝑝2(s^−1)	0.44	2.80	300.89
𝑠𝛼𝑝2	Slope value for 𝛼𝑝2(mV^−1)	−4.98	−4.99	−0.20
𝑘𝛽𝑝2	Maximum value of 𝛽𝑝2(s^−1)	3851.95	4612.17	4030.31
𝑠𝛽𝑝2	Slope value for 𝛽𝑝2(mV^−1)	0.26	0.70	0.02
𝐸𝛼𝛽𝑝2	𝐸50 value for 𝛼𝑝2 and 𝛽𝑝2(mV)	−47.98	−70.14	−51.73
𝑘𝛼𝑞2	Maximum value of 𝛼𝑞2(s^−1)	4.36	9.95	16.86
𝑠𝛼𝑞2	Slope value for 𝛼𝑞2(mV^−1)	3.51	3.04	0.20
𝑘𝛽𝑞2	Maximum value of 𝛽𝑞2(s^−1)	43.47	62.65	52.61
𝑠𝛽𝑞2	Slope value for 𝛽𝑞2(mV^−1)	−4.47	−4.67	−0.18
𝐸𝛼𝛽𝑞2	𝐸50 value for 𝛼𝑞2 and 𝛽𝑞2(mV)	−36.24	−69.46	−75.74
𝑔𝐿	Maximum 𝐼𝐿 conductance (μS/cm^2)	3.70	4.00	1.74
𝐸rev,𝐿	Reversal potential of 𝐼𝐿(mV)	−42.59	−69.32	−58.98