Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Table 3

Parameter values for LA multidataset-based optimisation.

Parameter	Description	Run 1	Run 2	Run 3
𝑔1	Maximum 𝐼1 conductance (μS · cm^−2)	3044.83	1926.84	4547.51
𝐸rev,1	Reversal potential of 𝐼1(mV)	5.00𝑒−4	2.50𝑒−2	9.54𝑒−2
𝑘𝛼𝑝1	Maximum value of 𝛼𝑝1(s^−1)	4483.62	4425.83	4619.86
𝑠𝛼𝑝1	Slope value for 𝛼𝑝1(mV^−1)	−9.21𝑒−2	−7.72𝑒−2	−5.16𝑒−2
𝑘𝛽𝑝1	Maximum value of 𝛽𝑝1(s^−1)	0.21	11.60	20.29
𝑠𝛽𝑝1	Slope value for 𝛽𝑝1(mV^−1)	0.196	0.197	0.199
𝐸𝛼𝛽𝑝1	𝐸50 value for 𝛼𝑝1 and 𝛽𝑝1(mV)	−28.97	−41.00	9.25
𝑘𝛼𝑞1	Maximum value of 𝛼𝑞1(s^−1)	1375.78	2117.98	1076.29
𝑠𝛼𝑞1	Slope value for 𝛼𝑞1(mV^−1)	−0.20	−0.194	−0.196
𝑘𝛽𝑞1	Maximum value of 𝛽𝑞1(s^−1)	4761.23	3987.49	4844.62
𝑠𝛽𝑞1	Slope value for 𝛽𝑞1(mV^−1)	3.20𝑒−3	8.00𝑒−4	2.80𝑒−3
𝐸𝛼𝛽𝑞1	𝐸50 value for 𝛼𝑞1 and 𝛽𝑞1(mV)	21.57	27.50	15.69
𝑔2	Maximum 𝐼2 conductance (μS · cm^−2)	42.24	29.84	66.49
𝐸rev,2	Reversal potential of 𝐼2(mV)	−80.00	−80.00	−80.14
𝑘𝛼𝑝2	Maximum value of 𝛼𝑝2(s^−1)	115.88	19.19	82.99
𝑠𝛼𝑝2	Slope value for 𝛼𝑝2(mV^−1)	−0.136	−0.117	−0.132
𝑘𝛽𝑝2	Maximum value of 𝛽𝑝2(s^−1)	217.08	164.94	283.28
𝑠𝛽𝑝2	Slope value for 𝛽𝑝2(mV^−1)	0.20	0.20	0.20
𝐸𝛼𝛽𝑝2	𝐸50 value for 𝛼𝑝2 and 𝛽𝑝2(mV)	−65.89	−68.28	−60.91
𝑘𝛼𝑞2	Maximum value of 𝛼𝑞2(s^−1)	1210.40	985.06	1311.51
𝑠𝛼𝑞2	Slope value for 𝛼𝑞2(mV^−1)	−0.20	−0.193	−0.20
𝑘𝛽𝑞2	Maximum value of 𝛽𝑞2(s^−1)	2603.48	2516.13	3055.08
𝑠𝛽𝑞2	Slope value for 𝛽𝑞2(mV^−1)	4.00𝑒−4	1.15𝑒−2	1.20𝑒−3
𝐸𝛼𝛽𝑞2	𝐸50 value for 𝛼𝑞2 and 𝛽𝑞2(mV)	−99.87	−97.95	−71.00
𝑔3	Maximum 𝐼3 conductance (μS · cm^−2)	7192.04	4338.65	3904.66
𝐸rev,3	Reversal potential of 𝐼3(mV)	51.31	37.11	59.56
𝑘𝛼𝑝3	Maximum value of 𝛼𝑝3(s^−1)	64.45	129.11	79.20
𝑠𝛼𝑝3	Slope value for 𝛼𝑝3(mV^−1)	−0.09	−9.41𝑒−2	−0.104
𝑘𝛽𝑝3	Maximum value of 𝛽𝑝3(s^−1)	4309.81	4587.86	4598.48
𝑠𝛽𝑝3	Slope value for 𝛽𝑝3(mV^−1)	2.44𝑒−2	3.61𝑒−2	2.73𝑒−2
𝐸𝛼𝛽𝑝3	𝐸50 value for 𝛼𝑝3 and 𝛽𝑝3(mV)	−39.76	−39.20	−39.52
𝑘𝛼𝑞3	Maximum value of 𝛼𝑞3(s^−1)	252.37	439.94	365.37
𝑠𝛼𝑞3	Slope value for 𝛼𝑞3(mV^−1)	9.78𝑒−2	0.118	0.10
𝑘𝛽𝑞3	Maximum value of 𝛽𝑞3(s^−1)	8.01	8.38	5.46
𝑠𝛽𝑞3	Slope value for 𝛽𝑞3(mV^−1)	−0.106	−0.073	−0.176
𝐸𝛼𝛽𝑞3	𝐸50 value for 𝛼𝑞3 and 𝛽𝑞3(mV)	−96.83	−99.51	−95.50
𝑔4	Maximum 𝐼4 conductance (μS · cm^−2)	39997.9	39857.1	38120.4
𝐸rev,4	Reversal potential of 𝐼4(mV)	72.48	62.36	75.24
𝑘𝛼𝑝4	Maximum value of 𝛼𝑝4(s^−1)	2392.17	2330.46	1884.15
𝑠𝛼𝑝4	Slope value for 𝛼𝑝4(mV^−1)	−0.159	−0.15	−0.161
𝑘𝛽𝑝4	Maximum value of 𝛽𝑝4(s^−1)	4999.04	4995.38	4938.09
𝑠𝛽𝑝4	Slope value for 𝛽𝑝4(mV^−1)	0.173	0.189	0.166
𝐸𝛼𝛽𝑝4	𝐸50 value for 𝛼𝑝4 and 𝛽𝑝4(mV)	−48.04	−48.21	−48.04
𝑘𝛼𝑞4	Maximum value of 𝛼𝑞4(s^−1)	46.66	48.78	22.51
𝑠𝛼𝑞4	Slope value for 𝛼𝑞4(mV^−1)	0.132	0.125	0.124
𝑘𝛽𝑞4	Maximum value of 𝛽𝑞4(s^−1)	1309.81	1172.17	1677.50
𝑠𝛽𝑞4	Slope value for 𝛽𝑞4(mV^−1)	−0.18	−0.1.86	−0.16
𝐸𝛼𝛽𝑞4	𝐸50 value for 𝛼𝑞4 and 𝛽𝑞4(mV)	−73.25	−74.12	−64.6
𝑔5	Maximum 𝐼5 conductance (μS · cm^−2)	3577.89	4188.07	3353.90
𝐸rev,5	Reversal potential of 𝐼5(mV)	5.51	3.62	7.54
𝑘𝛼𝑝5	Maximum value of 𝛼𝑝5(s^−1)	1943.58	1303.25	1115.88
𝑠𝛼𝑝5	Slope value for 𝛼𝑝5(mV^−1)	−0.199	−0.20	−0.197
𝑘𝛽𝑝5	Maximum value of 𝛽𝑝5(s^−1)	42.81	57.75	38.07
𝑠𝛽𝑝5	Slope value for 𝛽𝑝5(mV^−1)	1.68𝑒−2	1.16𝑒−2	1.33𝑒−2
𝐸𝛼𝛽𝑝5	𝐸50 value for 𝛼𝑝5 and 𝛽𝑝5(mV)	26.49	20.86	30.38
𝑘𝛼𝑞5	Maximum value of 𝛼𝑞5(s^−1)	433.93	668.38	497.48
𝑠𝛼𝑞5	Slope value for 𝛼𝑞5(mV^−1)	4.00𝑒−4	1.06𝑒−2	1.50𝑒−3
𝑘𝛽𝑞5	Maximum value of 𝛽𝑞5(s^−1)	1244.48	884.84	985.96
𝑠𝛽𝑞5	Slope value for 𝛽𝑞5(mV^−1)	−0.176	−9.46𝑒−2	−4.68𝑒−2
𝐸𝛼𝛽𝑞5	𝐸50 value for 𝛼𝑞5 and 𝛽𝑞5(mV)	−98.74	−92.40	−97.38
𝑔𝐿	Maximum 𝐼𝐿 conductance (μS · cm^−2)	107.47	123.02	92.50
𝐸rev,𝐿	Reversal potential of 𝐼𝐿(mV)	−99.98	−99.93	−99.89