Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Table 5

Parameter values for random-paced LA optimisation.

Parameter	Description	𝐼1	𝐼2	𝐼3	𝐼4	𝐼5	𝐼6	𝐼7	𝐼𝐿
𝑔	Maximum conductance (µS/cm^2)	3791.62	1112.87	24.99	334.03	5211.15	615.19	39984.07	12.96
𝐸rev	Reversal potential (mV)	−99.82	−90.46	−60.73	−27.89	53.14	30.14	73.64	−82.72
𝑘𝛼𝑝	Maximum value of 𝛼𝑝(s^−1)	4680.75	2452.15	4309.86	1351.75	20.51	3406.11	1547.59
𝑠𝛼𝑝	Slope value for 𝛼𝑝(mV^−1)	−7.40𝑒−2	−0.19	−0.16	−0.20	−8.40𝑒−2	−0.19	−0.19
𝑘𝛽𝑝	Maximum value of 𝛽𝑝(s^−1)	1577.04	17.13	1882.61	97.24	1035.90	4991.79	4097.16
𝑠𝛽𝑝	Slope value for 𝛽𝑝(mV^−1)	0.17	3.6𝑒−2	0	2.10𝑒−4	1.8𝑒−4	7.40𝑒−2	0.15
𝐸𝛼𝛽𝑝	𝐸50 value for 𝛼𝑝 and 𝛽𝑝(mV)	−99.90	22.84	14.65	−64.50	7.32	−43.38	−72.40
𝑘𝛼𝑞	Maximum value of 𝛼𝑞(s^−1)	8.78	133.46	201.88	1342.22	967.19	230.35	4.50
𝑠𝛼𝑞	Slope value for 𝛼𝑞(mV^−1)	0	1.20𝑒−3	0.19	0.20	0.20	0.17	0.19
𝑘𝛽𝑞	Maximum value of 𝛽𝑞(s^−1)	4976.46	1285.70	3.7𝑒−3	2100.13	145.50	19.01	1159.70
𝑠𝛽𝑞	Slope value for 𝛽𝑞(mV^−1)	0	−0.11	−3.1𝑒−2	−0.16	−3.40𝑒−2	−0.19	−0.19
𝐸𝛼𝛽𝑞	𝐸50 value for 𝛼𝑞 and 𝛽𝑞(mV)	−67.02	−94.50	−21.182	−100	0.32	−100	−99.88