Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Table 7

Parameter values for drug-specific optimisation.

Parameter	Description	𝐼1	𝐼2	𝐼3	𝐼4	𝐼𝐿
𝑔	Maximum conductance (µS/cm^2)	97	127.61	2438.40 (Control)	12279.67	13.58
				1562.28 (E-4031)
𝐸rev	Reversal potential (mV)	−55.54	−97.79	−79.96	43.39	−99.56
𝑘𝛼𝑝	Maximum value of 𝛼𝑝(s^−1)	4988.66	3178.26	3128	2545.56
𝑠𝛼𝑝	Slope value for 𝛼𝑝(mV^−1)	−8.40𝑒−2	−6.80𝑒−3	−0.2	−9.386𝑒−2
𝑘𝛽𝑝	Maximum value of 𝛽𝑝(s^−1)	2383.24	4828.39	72.52	1965.64
𝑠𝛽𝑝	Slope value for 𝛽𝑝(mV^−1)	0.19	1.70𝑒−3	1.14𝑒−2	2.40𝑒−4
𝐸𝛼𝛽𝑝	𝐸50 value for 𝛼𝑝 and 𝛽𝑝(mV)	−89.62	16.61	9.81	7.38
𝑘𝛼𝑞	Maximum value of 𝛼𝑞(s^−1)	587.81	85.64	162.53	0.83
𝑠𝛼𝑞	Slope value for 𝛼𝑞(mV^−1)	−0.1	−1.50𝑒−5	2.54𝑒−2	0.2
𝑘𝛽𝑞	Maximum value of 𝛽𝑞(s^−1)	4049.79	920.57	185.48	12.01
𝑠𝛽𝑞	Slope value for 𝛽𝑞(m𝑉^−1)	1.90𝑒−2	0.184	−0.14	−7𝑒−4
𝐸𝛼𝛽𝑞	𝐸50 value for 𝛼𝑞 and 𝛽𝑞(mV)	−84.76	−17.22	−99.92	−22.4