Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity

Table 9

Parameter values for tissue-specific optimisation.

Parameter	Description	𝐼1	𝐼2	𝐼3	𝐼4	𝐼5	𝐼6	𝐼7	𝐼𝐿
𝑔	Maximum conductance (µS/cm^2)	1577.21	1154.71	24.99	1014.53	2469.15	1376.76	15.83	10.08
	cSAN (upper)/RA (lower)	7526.58	66.55	76.99	50.00	2591.45	370.33	39997.86	4.30𝑒−2
𝐸rev	Reversal potential (mV)	−99.65	−97.08	−60.94	−29.09	63.89	30.66	80.96	−91.40
𝑘𝛼𝑝	Maximum value of 𝛼𝑝(s^−1)	4843.48	2636.70	4265.53	1197.10	25.37	3472.10	2083.24
𝑠𝛼𝑝	Slope value for 𝛼𝑝(mV^−1)	−9.09𝑒−2	−0.168	−0.131	−0.1.99	−8.54𝑒−2	−18.05𝑒−2	−0.196
𝑘𝛽𝑝	Maximum value of 𝛽𝑝(s^−1)	2227.67	18.19	1505.24	138.93	1448.56	4999.96	4601.00
𝑠𝛽𝑝	Slope value for 𝛽𝑝(mV^−1)	0.175	2.65𝑒−2	2.76𝑒−4	0.21𝑒−3	7.27𝑒−5	8.52𝑒−2	0.158
𝐸𝛼𝛽𝑝	𝐸50 value for 𝛼𝑝 and 𝛽𝑝(mV)	−96.10	−1.19	23.46	−61.64	−0.127	−43.024	−56.47
𝑘𝛼𝑞	Maximum value of 𝛼𝑞(s^−1)	19.74	19.48	357.63	1068.00	1118.86	620.38	78.65
𝑠𝛼𝑞	Slope value for 𝛼𝑞(mV^−1)	−4.23𝑒−3	2.6𝑒−3	0.198	0.20	0.20	18.47𝑒−2	0.195
𝑘𝛽𝑞	Maximum value of 𝛽𝑞(s^−1)	4974.17	1236.21	209.24	2699.34	303.27	64.29	455.47
𝑠𝛽𝑞	Slope value for 𝛽𝑞(mV^−1)	1.13𝑒−4	−0.117	−2.55𝑒−2	−0.177	−1.99𝑒−2	−0.187	−0.181
𝐸𝛼𝛽𝑞	𝐸50 value for 𝛼𝑞 and 𝛽𝑞(mV)	−42.60	−98.56	−36.83	−100.00	−4.22	−83.15	−92.11