Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters: A Practical Approach for Routine Clinical Practice in Radiation Oncology

Table 6

Previous studies for radiotherapy induced acute toxicity in terms of breast irradiation [34].

Authors	Patients	Dose/fraction (Gy)	Acute toxicity; ≥G2 (%)
Storey et al. [35]	189	70–78*; 2	—
Fiorino et al. [36]	245	70–78; 2	—
Greco et al. [37]	135	76; 2	—
Peeters et al. [38]	641	78; 2	—
Kupelian et al. [39]	770	70; 2.5	9
Kuban et al. [40]	301	70–78; 2	—
Vavassori et al. [41]	1123	≥70; 2	25.1

∗Two arms: first arm treated with conventional “box technique,” dose, 70 Gy; second arm treated with 3D conformal, dose, 78 Gy.