Research Article
Additive Hazard Regression Models: An Application to the Natural History of Human Papillomavirus
Table 1
Results from semiparametric additive hazard model fitting for oncogenic HPV and any HPV.
| | Oncogenic HPV | Any HPV | | Effect estimate | SE* | P value | Effect estimate | SE | P value |
| HIV/CD4 Count | | | | | | | HIV- (ref†) | 0 | | | 0 | | | CD4 > 500 | 0.0343 | 0.0075 | <0.0001 | 0.0878 | 0.0159 | <0.0001 | CD4: 200–500 | 0.0779 | 0.0086 | <0.0001 | 0.2264 | 0.0214 | <0.0001 | CD4 < 200 | 0.1395 | 0.0163 | <0.0001 | 0.2954 | 0.0427 | <0.0001 | Age | | | | | | | <30 (ref) | 0 | | | 0 | | | 30–34 | −0.0213 | 0.0103 | 0.04 | −0.0472 | 0.0205 | 0.02 | 35–39 | −0.0425 | 0.0097 | <0.0001 | −0.0547 | 0.0202 | 0.01 | 40–44 | −0.0502 | 0.0106 | <0.0001 | −0.0282 | 0.0230 | 0.22 | ≥45 | −0.0408 | 0.0137 | 0.003 | −0.0623 | 0.0274 | 0.02 | Race | | | | | | | White (ref) | 0 | | | 0 | | | Black | 0.0140 | 0.0096 | 0.15 | 0.0517 | 0.0198 | 0.01 | Hispanic | −0.0030 | 0.0102 | 0.77 | 0.0118 | 0.0212 | 0.58 | Other | −0.0090 | 0.0191 | 0.64 | 0.0661 | 0.0485 | 0.17 | Smoking | | | | | | | Never (ref) | 0 | | | 0 | | | Former | 0.0034 | 0.0098 | 0.73 | 0.0060 | 0.0212 | 0.78 | Current | 0.0224 | 0.0079 | 0.005 | 0.0495 | 0.0166 | 0.003 | Sex‡ | | | | | | | 1 (ref) | 0 | | | 0 | | | 0 | 0.0003 | 0.0082 | 0.97 | −0.0255 | 0.0162 | 0.12 | 2 | 0.0140 | 0.0122 | 0.25 | 0.0556 | 0.0256 | 0.03 | ≥3 | 0.0158 | 0.0128 | 0.22 | 0.1217 | 0.0330 | 0.0002 |
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Standard error. †Reference category. ‡Number of male sexual partner in past 6 months.
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