Table 1: Association analysis of the 16 overlapping SNPs in both stages of bipolar study.

SNP Chr Pooling (Stage 1) Individual genotyping (Stage 2)
SAM CA CN CA CN Model OR value

SNP 1 3 7 189 5 0.17 0.36 0.21 0.35 DOM 0.5 0.00002*
SNP 2 3 2 363 15 0.23 0.43 0.22 0.33 DOM 0.6 0.00018*
SNP 3 6 28 873 152 0.53 0.38 0.45 0.33 ALL 1.6 0.00085*
SNP 4 4 36 124 58 0.31 0.44 0.33 0.44 ALL 0.7 0.00142*
SNP 5 21 13 531 64 0.58 0.41 0.55 0.43 ADD 1.5 0.00294*
SNP 6 6 41 1308 346 0.41 0.28 0.34 0.25 ADD 1.5 0.00651*
SNP 7 16 10 110 18 0.33 0.49 0.34 0.45 ALL 0.7 0.00725*
SNP 8 13 48 596 126 0.56 0.42 0.52 0.40 ALL 1.4 0.00785*
SNP 9 2 101 7484 2795 0.50 0.40 0.48 0.41 ADD 1.4 0.00960*
SNP 10 4 5 19 1 0.27 0.46 0.27 0.36 ALL 0.7 0.00971*
SNP 11 14 40 4678 1025 0.36 0.49 0.42 0.53 DOM 0.7 0.01275*
SNP 12 18 20 393 47 0.49 0.33 0.47 0.36 ALL 1.4 0.01604*
SNP 13 3 6 694 44 0.33 0.53 0.39 0.49 DOM 0.7 0.01631*
SNP 14 7 8 36 2 0.31 0.47 0.37 0.45 ADD 0.8 0.06830
SNP 15 5 21 762 57 0.37 0.56 0.35 0.42 DOM 0.8 0.09806
SNP 16 7 22 210 21 0.35 0.53 0.31 0.38 ALL 0.8 0.13530

Chr: chromosome; : rank based on rerank approach; : rank based on -test; SAM: rank based on SAM with ; CA: MAF of cases; CN: MAF of controls; Model: genetic model with the most significant result among allelic (ALL), dominant (DOM), recessive (REC), and additive (ADD) genetic models; OR (odds ratio) and value: estimated by the simple logistic regression under the genetic model with the most significant result (* value 0.05).