Table 2: Set-based analysis of the 8 selected genes under different models of association test.

Gene NSNP Allelic model Dominant model Recessive model Additive model
NSIG ISIG EMP NSIG ISIG EMP NSIG ISIG EMP NSIG ISIG EMP

Gene 1 11 0 0 1.000 1 1 0.375 0 0 1.000 0 0 1.000
Gene 2 12 1 1 0.443 1 1 0.069 0 0 1.000 1 1 0.415
Gene 3 10 0 0 1.000 0 0 1.000 0 0 1.000 0 0 1.000
Gene 4 9 2 1 0.057 2 1 0.190 1 1 0.135 2 1 0.005*
Gene 5 11 4 2 0.008* 3 2 0.011* 1 1 0.008* 4 2 0.005*
Gene 6 10 1 1 0.007* 2 2 0.129 1 1 0.054 1 1 0.010*
Gene 7 12 1 1 0.107 1 1 0.038* 0 0 1.000 1 1 0.088
Gene 8 4 1 1 0.042* 0 0 1.000 1 1 0.046* 1 1 0.037*

NSNP: number of SNPs in a set; NSIG: total number of SNPs below value with 0.05; ISIG: number of significant SNPs also passing LD criterion on an -squared threshold of 0.5; EMP: empirical set-based value (*EMP < 0.05).