Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction

Table 4

Methods for mimotope-based B-cell epitopes prediction.

Method	Online service (program)	Brief notes
FINDMAP [64]	Not available	Map motif to antigen sequence
EPIMAP [65]	Not available	Improved version of FINDMAP
MIMOP/MimAlign [66]	Available upon request	Based on four multiple sequence alignments
MEPS [67]	http://www.caspur.it/meps	Surface mimicking peptides
3DEX [68]	Not available	Physicochemical neighborhood
MIMOX [88]	http://immunet.cn/mimox/	The first free web tool
MIMOP/MimCons [66]	Available upon request	Clustering the mimotope sequences
Mapitope [69, 70]	http://pepitope.tau.ac.il	The first method based on amino acid pairs
Denisova^a [71–73]	Not available	Derivative method of Mapitope
SiteLight [74]	Not available	A patch-based method
EpiSearch [75]	http://curie.utmb.edu/episearch.html	An automated sequence analysis based on sequence and 3D profiles
PepSurf [76]	http://pepitope.tau.ac.il	The first graph-based method
Pep-3D-Search [77]	http://kyc.nenu.edu.cn/Pep3DSearch	Ant colony optimization algorithm
MimoPro [78]	http://informatics.nenu.edu.cn/MimoPro	Based on both patch and graph searching

aThe name of the first author is used if the method has no name.