CellDiff3D visualization of the simulated myeloid differentiation network. Each image is a still taken from renderings of VRML code produced by the modeling method. The transcription factors and their regulatory interactions that comprise the GRN are shown in Figure 3. Each sphere is one of the myeloid cell types shown in Figure 1. Each row shows three orthographic views of cell type transitions derived from runs using the wild-type transcription factor network (top row of panel) or with transcription factor mutations in which the first transcription factor listed does not interact with the second transcription factor (lower rows of panel). The distance between each pair of cell types is the separation and the arrow direction and thickness are flux. For clarity, low flux edges are not shown. Lavender arrows show normal differentiation or dedifferentiation along the standard lineage tree from a specialized cell to its immediate progenitor; black arrows show transdifferentiation, off-differentiation, or off-dedifferentiation.
