Research Article

Application of Multivariate Modeling for Radiation Injury Assessment: A Proof of Concept

Table 1

The 106 CBC, blood chemistry parameters, and related ratios based from the 7 time points (0, 7, 10, 14, 17, 21, and 25 d after irradiation). Variables marked with an asterisk indicate the 32 selected for entry in the correlation matrix.

CBC panel parametersBlood chemistry panel parametersRatios of CBC and blood chemistry parameters

*Hematocrit (relative volume of erythrocytes) (HCT) *Alanine transaminase level (ALT)TRIGL/TPCK/ALB
*Hemoglobin concentration (HGB)Albumin level (ALB)#BASO/WBCCK/ALB
*Mean corpuscular (erythrocyte) volume (MCV) *Alkaline phosphatase level (ALKP)#EOS/WBCCK/TP
*Mean corpuscular hemoglobin (MCH)Amylase level (AMYL)#LUC/WBCCK/TP
*Mean corpuscular hemoglobin concentration (MCHC) *Aspartate aminotransferase level (AST)ALC/WBCCO2/PO4
*Mean platelet (thrombocyte) volume (MPV)Bilirubin level (BILI)#MONO/WBCGGT/ALB
*Number of basophils (# BASO) *Blood urea nitrogen level (BUN)#RETIC/WBC,GGT/TP
*Number of eosinophils (# EOS)Calcium level (Ca)%EOS/WBCGLU/ALB
*Number of leucocytes (# LUC) *Carbon dioxide concentration (CO2)%LYMPH/WBCHCT/ALB
*Number of lymphocytes (# ALC)Chloride level (Cl)%NEUT/WBCHGB/RBC
*Number of mononuclear cells (# MONO) Cholesterol Level (CHOL)%RETIC/WBCK/Na
*Number of neutrophils (# ANC) *Creatine kinase level (CK)ALB/TPLDH/ALB
*Number of reticulocytes (# RETIC) *Creatinine level (CR)ALKP/ALBLDH/TP
*Percentage of basophils (% BASO) Gamma-glutamyl transferase level (GGT)ALKP/TPLPS/ALB
*Percentage of eosinophils (% EOS) Glucose level (GLU)ALT/ALBMCH/RBC
*Percentage of leukocytes (% LUC) *Lactate dehydrogenase level (LDH)ALT/TPMCHC/RBC
*Percentage of lymphocytes (ALC)Lipase level (LPS)AMYL/ALBMCV/WBC
Percentage of mononuclear cells (% MONO)Phosphate level (PO4)AST/ALBMPV/WBC
*Percentage of neutrophils (% NEUT) *Potassium level (K)AST/TPNa/K
*Percentage of reticulocytes (% RETIC) Sodium level (Na)BASO/%LUCANC//WBC
*Platelet count (# APC)Total protein level (TP)BILI/ALBAPC/WBC
*Red blood cell count (# RBC)Triglyceride level (TRIGL)BILI/TPPO4/CO2
*White blood cell count (# WBC) *Uric acid level (URIC)BUN/ALBRBC/WBC
Ca/ALBTP/ALB
Ca/PO4TRIG/ALB
Ca/TPTRIGL/CHOL
CHOL/ALBURIC/ALB
CHOL/TPURIC/BUN
CHOL/TRIGURIC/TP
Cl/NaWBC/RBC