Application of Multivariate Modeling for Radiation Injury Assessment: A Proof of Concept

Table 3

Quantitative measures to assess radioresponses for selected seven blood variables including: a) initial time of change and relative fold change, b) nadir time window and relative nadir fold changes, and c) time until return to baseline levels.

Blood parameters	Baseline range	Initial time of change (day)	Fold change					Nadir time (day)	Nadir values fold change					Return to baseline time (day)
				RSD *(+/−)						RSD *(+/−)
ANC	2.82–4.30 × 10^3L^−1	7	3.7	1.6	−3.25	0.01	8	10–17	23.89	8.83	−4.3	0.004	8	21
ALC	1.41–1.78 × 10^3L^−1	7	3	0.09	−8.35	0.01		7–17	7.98	1.53	−8.5	0.0001	8	25
APC	321.82–370.74 × 10^3L^−1	7	2.19	0.37	−5.32	0.0001	8	10–17	11.32	3.26	−13	0.0001	8	—
HCT	37.93–39.99 (%)	10	1	4.54	−1.65	0.01		17–25	1.33	0.08	−5.9	0.0006	8	—
AST	36.86–44.78 U/L^−1	7	1.82	0.23	3.81	0.006	8	—	—	—	—	—	8	10
CK	304.57–681.71 U/L^−1	7	3.12	1.4	1.65	0.04	8	—	—	—	—	—	8	10
LDH	846.41–1185.83 U/L^−1	7	1.68	0.37	2.34	0.05	8	—	—	—	—	—	8	10

Relative Standard Deviation (RSD).