Application of Multivariate Modeling for Radiation Injury Assessment: A Proof of Concept

Table 4

CBC and CBC-SCHEM RC3 model equations.

(a) “CBC” RC3 model

RC3 = 1.93 + (0.09) (TIME) + (−0.06) (ANC) + (−0.36) (ALC) + ) (APC)
R ^2 = 0.908, P = 0.00001, n = 92, F = 39.3, SE  of  the  estimate = ±1.01
Predictor	Value	value	value
	1.93	12.61	0.00
TIME	0.09	13.06	0.00
ANC	−0.06	−1.87	0.06
ALC	−0.36	−4.53	0.00
APC		−4.81	0.00

(b) “CBC-SCHEM” RC3 model

*RC3 = 0.42 + (0.11) (TIME) + (−0.06) (ANC) + (−0.26) (ALC) + () (APC) + (0.01) (AST) + () (CK) + (0.02) (HCT) + () (LDH)
R ^2 = 0.933, P = 0.00001, n = 92, F =36, SE  of  the  estimate = ±0.88
Predictor	Value	value	value
	0.42	0.85	0.39
TIME	0.11	12.82	0.00
ANC	−0.06	−2.06	0.04
ALC	−0.26	−3.50	0.00
APC		−5.52	0.00
AST	0.01	2.71	0.00
CK		1.81	0.07
HCT	0.02	1.79	0.07
LDH		−0.61	0.54

Note. The value represents the ratio of the -coefficient over its SE. The value represents the significance of the value.
(Adding of CK and LDH enables the model to pass the requirements of linear-least-squares analysis.)
See text 2.7 for units values of the variables shown in both algorithms.