Application of Multivariate Modeling for Radiation Injury Assessment: A Proof of Concept

Table 5

Receiving operator curve analysis of single and combination of blood variables at the six time points 7, 10, 14, 17, 21, and 25 d after irradiation equations.

ROC AUC values at 95% CL, comparison of RC0 and RC3
Time after irradiation, d
Blood variable combination		7 d	10 d	14 d	17 d	21 d	25 d	Pooled
ALC	AUC	1	1	1	1	0.85	1.0	0.98
	95% CL					0.04–1.00	0.93–1.00	0.94–1.00
ANC	AUC	0.96	1	1	1	0.43	0.56	0.88
	95% CL	0.90–1.00				0.00–0.90	0.20–0.83	0.77–0.98
APC	AUC	0.99	1	1	1	0.76	0.67	0.94
	95% CL	0.97–1.00				0.00–1.00	0.00–1.00	0.85–1.00
HCT	AUC	0.58	0.74	0.88	0.99	0.99	0.98	0.92
	95% CL	0.05–1.00	0.02–0.98	0.08–0.99	0.98–1.00	0.98–1.00	0.94–1.00	0.84–0.99
LDH	AUC	0.74	0.51	0.54	0.48	0.45	0.47	0.42
	95% CL	0.04–0.97	0.25–0.78	0.24–0.84	0.17–0.85	0.16–0.86	0.20–0.77	0.29–0.66
CK	AUC	0.91	0.49	0.48	0.51	0.5	0.47	0.50
	95% CL	0.02–0.98	0.34–0.65	0.17–0.85	0.12–0.86	0.30–0.71	0.24–0.76	0.36–0.65
AST	AUC	0.96	0.50	0.58	0.56	0.50	0.54	0.44
	95% CL	0.92–1.00	0.30–0.75	0.20–0.82	0.09–0.91	0.19–0.81	0.33–0.75	0.20–0.65
“CBC” RC3 model
ALC, ANC, APC	AUC	1	1	1	1	0.87	0.92	0.97
	95% CL					0.51–1.00	0.61–1.00	0.91–1.00
“CBC-SCHEM” RC3 model
ALC, ANC, APC, HCT, LDH, CK, AST	AUC	1	1	1	1	0.95	0.96	0.99
	95% CL	0.99-1.00	0.95–1.00	0.95–1.00	0.98–1.00	0.76–1.00	0.82–1.00	0.97–1.00